Laboratories of molecular cytogenetics and cytogenomics

We are focused on research

The main focus of these laboratories is research of human genome instability at the level of structural and numerical changes of chromosomes using molecular cytogenetic or cytogenomic methods. The obtained findings have important applications in clinical medicine, they serve to reveal the causes of some genetically determined congenital diseases or to characterize the biological properties of malignant tumors.

The research activities of our laboratories are focused on the study of chromosomal aberrations using metaphase and interphase fluorescence in situ hybridization (FISH) techniques, MLPA techniques and array-CGH, optical genome mapping and next-generation sequencing (NGS) technologies. In cooperation with the Institute of Medical Genetics of the Brno University Hospital and a number of other medical departments, we participate in the rapid introduction of specialized molecular cytogenetic examinations into clinical practice. We cooperate closely with other cytogenetic laboratories of the Cytogenomics Section of the CMBG IHOK FN Brno, where molecular cytogenetic and cytogenomic analyses are performed for the needs of prenatal genetic diagnostics, postnatal cytogenetics and oncocytogenetics.