Laboratory of Molecular Diagnostics of Microorganisms | MUNI SCI Department of Experimental Biology

Laboratory of Molecular Diagnostics of Microorganisms (LMDM)

Join our work to

✓ improve the treatment of staphylococcal infections
✓ introduce new methods for molecular diagnostics
✓ participate in the development of new medications
✓ explain the spread of antibiotic resistant pathogenic bacteria
✓ discover new microorganisms

Achieve research successes in the fight against bacterial pathogens with us!

to get involved in research We are looking for students for new bachelor’s thesis topics

Program of laboratory seminar Bi7891

(Monday, 10:00-11:50; UKB, E25/209)

30 Jun–12 Jul

Wwe are participating in the conference The Viruses of Microbes (VoM) - the world's leading event for research on viruses of microorganisms

the entire program

News

Conformational changes of the baseplate regulating tail contraction of Staphylococcus phage 812

Bíňovský J, Šiborová M, Zlatohurska M et al. The EMBO Journal 2026

Congratulations to Ján Bíňovský on his new paper - How bacteriophage recognizes and penetrates the cell wall of Staphylococcus aureus: From atomic structure to targeted phage therapy.

For the academic year 2026/2027, we are recruiting students for the following topics for research bachelor's theses for the Molecular Biology and Genetics study program (B-EMB)

Role extracelulárních vezikul v biologii a patogenezi gram-pozitivních bakterií (rešeršní ve spolupráci s Biofyzikálním ústavem AV ČR)
Co jsme se naučili o fágové terapii stafylokokových infekcí z preklinických zkoušek na myším modelu (rešeršní)
Molekulární mechanismy interakce stafylokokových bakteriofágů s biofilmem (rešeršní)
Mikroevoluce rezistence a virulence zoonotické linie Staphylococcus aureus ST398 v prostředí člověka a potravního řetězce (rešeršní, ve spolupráci s Ústavem veřejného zdraví LF MU)
Fágová terapie nové generace: Návrh a optimalizace řízené umělou inteligencí (rešeršní)

The combination of mupirocin and Kayvirus broadens the decolonization effect against Staphylococcus aureus

Siváková, Figallová, Botka et al., Applied Microbiology and Biotechnology, 2026
In collaboration with the Faculty of Medicine of MU, we have demonstrated that the therapeutic phage of the Kayvirus genus extends the effect of mupirocin decolonization of S. aureus while preventing the development of resistance.

Antarctic Mokoshia rubra and Mokoshia mucilaginosa enhance growth and cadmium stress tolerance in Nicotiana species

Cooperation with the Section of Experimental Plant Biology ÚEB - Plant Physiology and Biochemistry 2025.
The species of the genus Massilia, which we have described from Antarctic environments, function as an important component of beneficial plant microbiomes.

Virion content unpacked by long-read sequencing: stress-induced changes in transmitted staphylococcal mobilome due to phage-satellite interactions

Botka al. Nucleic Acids Research 2025
We published a study focused on the spread of mobile genetic elements of bacteria, which have a significant impact on the emergence of multidrug-resistant pathogens. Their spread is enabled by temperate bacteriophages and their satellites, for which we have presented a new approach to monitor the genetic content of individual viral particles. We also demonstrated how therapeutic bacteriophages can be utilized to suppress the spread of these factors, thereby combating the global issue of antibiotic resistance.

CRISPR-Cas10-Assisted Structural Modification of Staphylococcal Kayvirus for Imaging and Biosensing Applications

Šimečková et al. ACS Synthetic Biology 2025
Congratulations to Hanka on her publication of a structurally modified bacteriophage with a number of advanced applications.

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