Research Collaboration

Our collaborations are focused on the applied research of bacteriophages for phage therapy, which is becoming a promising alternative therapy, due to the continual rise of resistance to antibiotics in pathogens causing serious diseases. In the past, in collaboration with pharmaceutical companies, we have contributed to the successful resolution of projects focused on the preparation and invention of new phage preparations for the treatment of staphylococcal infections. We also investigate the use of phage lytic enzymes prepared by genetic engineering methods as effective enzybiotics.

Experience to date and current activities

• The preparation of polyvalent staphyloccocal phages with a broader host-range
• The invention of the phage preparation Stafal® for the treatment of staphylococcal infections
• The development of diagnostic kits for identifying staphylococcal bacteriophages
• The design of genetic constructs and vectors for the expression of recombinant phage enzybiotics
• Our team is involved in the activities of the international Expert Round Table on Acceptance and Re-implementation of Bacteriophage Therapy

What we offer in the field of research and development

• Consultation in assessing the safety of phages for the preparation of remedies
• Bioinformatic analysis of the genomes of phages and their propagation strains
• Testing of the lytic effect of phages on bacterial strains
• Diagnostics and typing of clinically significant staphylococcus species

We are engaged in long-term collaborations with the following workplaces and firms in the Czech Republic and abroad

• Czech Collection of Microorganisms (CCM)
• CEITEC Masaryk University
• Department of Biology at the Faculty of Medicine MU
• National Reference Laboratory for Staphylococci
• Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital
• Department of Microbiology Faculty of Medicine and Dentistry UP Olomouc
• Veterinary research institute, Department of Bacteriology
• Department of Infection Biology, University of Tübingen
• Department of Medical Microbiology UMCG Groningen
• Department of Genetics, Faculty of Natural Sciences Comenius University in Bratislava
• Department of Microbiology Faculty of Medicine MU and FN U Svaté Anny in Brno
• The University Hospital Brno
• Institute of Analytical Chemistry of the CAS
• Institute of the Biophysics of the CAS
• Bohemia Pharmaceuticals s.r.o.
• Bioveta, a.s.
• MB Pharma s.r.o.