Virion content unpacked by long-read sequencing: stress-induced changes in transmitted staphylococcal mobilome due to phage-satellite interactions
Botka al. Nucleic Acids Research 2025
We published a study focused on the spread of mobile genetic elements of bacteria, which have a significant impact on the emergence of multidrug-resistant pathogens. Their spread is enabled by temperate bacteriophages and their satellites, for which we have presented a new approach to monitor the genetic content of individual viral particles. We also demonstrated how therapeutic bacteriophages can be utilized to suppress the spread of these factors, thereby combating the global issue of antibiotic resistance.
